Maximizing the effects of sublingual B12 will depend on the time and manner it is taken. You have to fully absorb all the nutrients that you introduce under your tongue. In order to do this, you should avoid eating solid food 30 minutes before and 30 minutes after taking the supplement. Read and follow carefully the instructions on the bottle or container so as to prevent an over dose. Take the nutrient at least every six hours or every 10 hours at the very least for maximum effect. You need this space of time to allow full absorption and utilization of the nutrients before your next dosage. You should also buy sublingual b12 that contains methylcobalam because it is the type used by your nervous system.